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Psychiatric and Cognitive Manifestations of Parkinson’s Disease
The goals of this observational study are to evaluate the causes, effects, and clinical correlates of psychiatric and cognitive symptoms in PD. While Parkinson’s Disease (PD) is often thought of as affecting movement only, most people with Parkinson’s also experience psychiatric and cognitive symptoms, sometimes from the disease itself, and sometimes as a side-effect of PD medications.
Learning, Memory, and Decision-Making in Parkinson’s Disease
The primary objective of this study is to understand how learning, memory, and decision making can be influenced, in people with PD and age-matched controls (people who do not have PD), by feedback, training, stimulus familiarity, and differences in motivation.
A Placebo and Active-Controlled Study of Preladenant in Subjects With Moderate to Severe Parkinson’s Disease
The goal of this interventional trial will test the hypothesis that A2a receptor antagonism can lead to improvement in the function of people with Parkinson’s, as measured by a reduction in “off” time.